Pro-Adapt (15ml) – Progesterone Hormone Therapy by BioMatrix


Pro-Adapt Progesterone

Support balanced female hormones with the aid of bioidentical plant-based oils to help increase progesterone and promote recovery from symptoms.

  • Maximize progesterone support with a micronized formula providing high absorption, in liquid form
  • Defend against headaches, mood swings, low libido, breast tenderness, weight gain, and more
  • Enjoy precision dosing and titration in a progesterone-only formula, to complement female hormone balancing protocols using hormones such as estriol

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Pro-Adapt Progesterone

Pro-Adapt Progesterone unlike other brands, separates its progesterone and estriol products, allowing for precision dosing and optimal results.

Please advise who your Dr or Health Practitioner is when requesting this supplement.

New 2018 Formula: Pro-Adapt Progesterone – Bioidentical Progesterone

Pro-Adapt Progesterone Key Benefits:

  • Micronized form for greater absorption.
  • Contains 4.0 mg of progesterone per drop.
  • Derived from extractions of the Wild Yam root (Dioscorea villosa).
  • Can be used in bioidentical hormone therapies to mimic natural progesterone.
  • Oil-based in a natural blend of premium mixed tocopherols and alpha-tocopherols.

Progesterone Support

Progesterone is found in both men and women, but it is uniquely important to women’s health and is one of critical hormones for the reproductive system. Maintaining balanced progesterone levels supports dozens of key components of health. Along with estrogen, these hormones regulate some of the body’s most important functions. If progesterone levels are depressed, estrogen dominance can occur, allowing this hormone to build up in your body and cause many problems, some severe in nature.

Every cell in the body has a receptor for progesterone, not just the uterus. It has many purposes: Progesterone impacts fluid retention, bone density, skin elasticity, libido, and more. An overlooked function of progesterone is its ability to promote nerve cell growth, which can create a calming effect, relieving stress and promoting brain health.

Bioidentical hormone replacement (BHRT) has become standard of care worldwide, as an alternative to pharmaceutical treatments, to help a woman feel better as she goes through life’s hormonal changes. BHRT therapies tend to be more careful, safe, and effective, given the harmonious relationship between the body’s own hormones and those delivered by botanically derived products like Pro-Adapt, and its sister formula, Est-Adapt (estriol oil blend).

The Pro-Adapt Advantage

Pro-Adapt contains progesterone which is extracted from the steroidal backbone of the Wild Yam root (Dioscorea villosa). It provides 4 mg of micronized progesterone per drop, ideal for refining personal dosages. Micronization is the process of reducing a material’s particle size to the micron or submicron level, thereby increasing absorption.

The Formula: Purpose

  • Progesterone plays a role in many body functions, including female-specific ones but also general functions, such as regulating blood pressure, promoting restful sleep, and fostering healthy mood. The progesterone in Pro-Adapt is bioidentical, meaning it has the same molecular structure as that produced by the body.
  • Vitamin E (mixed with tocopherols) is a blend of alpha-tocopherol and mixed tocopherols. Pro-Adapt does not use the common tocopheryl acetate form; acetate is cheap acid, used in wood glue. Pro-Adapt uses premium vitamin E in mixed tocopherol forms for enhanced stability and oxidative protection.
  • Rice Bran Oil is a reliable carrier which contributes to stability and viscosity of the oil formula.

Support for Low Progesterone:

  • Promotes menstrual regularity.
  • Reduces the symptoms of PMS and promotes calmness.
  • Helps prepare and maintain the body for pregnancy.
  • Helps with weight loss efforts.
  • Counteracts the effects of estrogen dominance.
  • Decreases menstrual bleeding.
  • May help promote fertility and allow for easier ovulation tracking.

Pro-Adapt Progesterone is a highly absorbable source of progesterone. Pro-Adapt is indicated whenever natural progesterone augmentation is required, and can be used for maintaining a healthy estrogen/progesterone balance. Lab testing will help determine each patient’s need for augmentation.

The Formula: Purpose & Science-Based Ingredients

Minimizes hot flashes and night sweats – During feminine transition periods, progesterone levels naturally decline and lead to these undesirable symptoms. A randomized control trial found that postmenopausal women who took micronized progesterone for 12 weeks experienced a lower number of hot flashes and night sweats [1]. Similarly, progesterone therapy for three months was effective in reducing these vasomotor symptoms in healthy menopausal women and did not cause depression [2].

Promotes a healthy night’s sleep – The evidence shows that progesterone supports healthy sleep patterns. When postmenopausal women with sleep disturbances were supplemented with progesterone for three weeks, they experienced improved time in slow-wave, deep sleep, and reduced nighttime awakenings. Researchers found that these changes were not linked with increased daytime fatigue or negative mood changes

Supports healthy vaginal lubrication – According to the evidence, postmenopausal women who were supplemented with progesterone-containing suppositories for six months exhibited improved vaginal secretions and endometrial thickness.

<p>Assists in bone mineralization – Progesterone promotes bone formation in pre- and possibly perimenopausal women. A clinical study reported that women over 65 years of age had higher bone mineral density and bone mineral content following progesterone therapy and calcium and vitamin D supplementation for three and a half years.

Protects the uterus – Progesterone prevents the enlargement—hyperplasia—of the uterus, thereby reducing the risk of uterine cancer. In a 1996 study, postmenopausal women who took micronized progesterone once daily for 12 days prior to going to bed had reduced hyperplastic changes in the uterus than women who took only estrogen.

FAQ: Est-Adapt and Pro-Adapt

How many drops of oil are in each bottle?

There are approximately 500 drops per bottle.

Why is the bottle only partially full?

The oil fills approximately 1/3rd of the bottle to allow for adequate shaking of the product before use, and to accommodate the glass pipette’s length and width.

What are some tips for handling the bottle?

Shake vigorously before use. If the oil seems to adhere to the bottom, slap the bottle on your palm a few times to loosen it, then shake vigorously. You can also dip the bottle in hot water for a few minutes to loosen contents after a period of not being used.

To best observe how much oil is left in your bottle, hold it up to bright light and tilt the bottle sideways. The dark amber glass bottle is used for protecting the oil and increasing stability.


Bottle size: 15 ml, approximately 500 drops.


Oil Hormone FAQ

How many drops of oil are in each bottle?

There are approximately 500 drops per bottle (at a price lower or equal to the competition, with 50% more product per bottle).

Why is the bottle only partially full?

The oil fills approximately 1/3rd of the bottle to allow for adequate shaking of the product before use, and to accommodate the glass pipette’s length and width.

Many BioMatrix customers have used Phyto-BL 4X™ and Progon-BL 4X™ and requested information comparing our new products, especially in terms of converting dosages. While similar in intent and purpose, there are some fundamental differences – and similarities – between Est-Adapt™ and Pro-Adapt™, and these other products.

BioMatrix Hormone Therapy

Bioidentical Hormone Replacement Therapy (BHRT) is an increasingly popular treatment for a variety of patient health complaints. Health professionals are turning to bioidentical hormones derived from wild yam, specifically Dioscorea villosa (plants containing unique compounds which are extracted as identical replicas of hormones the body produces). Technically, the body can’t distinguish bioidentical hormones from the ones produced in the body. With laboratory data combined with symptoms and patient histories, clinicians can determine therapies to help augment hormone levels and support the body’s innate hormone production.

The Hormones and Hormone Modifiers

BioMatrix DHEA, and Pregnenolone are formulated using extraction of the steroidal component of the wild yam (Dioscorea villosa). The active ingredients are suspended in an alcohol solution to optimize oral absorption. In contrast to micronized oral tablets, which appear to be absorbed only 40-50%, BioMatrix hormone absorption is approximately 95%.

BioMatrix Licorice Root Extract (LRE) is designed for use in supporting the adrenals when cortisol output is depressed. One of the primary compounds in licorice root is glycyrrhizin (a substance that has a molecular structure similar to corticosteroids). As such, LRE aids in hypoadrenalism by partially blocking the enzyme that converts cortisol to cortisone, thus sparing cortisol.

Est-Adapt and Pro-Adapt are oil-based formulas containing estriol and progesterone, respectively. They are used primarily for helping women to establish optimal levels of these key hormones to alleviate a myriad of symptoms. The dosing options and quality of ingredients in BioMatrix oil hormones is superior to the competition in numerous ways.

About Biomatrix:

Science and Purpose

BioMatrix was formed in 1998 with a single purpose: formulate dietary supplements that can prevent and resolve the impact of chronic stress. We provide health professionals with products specifically formulated to address the underlying causes of illness identified by functional lab testing.

Our formulas are the standard of care for intervention protocols and maintenance supplementation for thousands of health professionals and their patients.

Confirmed effective by clinical usage and laboratory monitoring, BioMatrix is a leader in supplementation for preventing, managing, and reversing health problems.

The clinical application of each BioMatrix product is specific and tested. No shortcuts are taken in the sourcing of quality raw materials.

Biomatrix – The Clinician’s Choice

Targeted at preventing and resolving the impact of chronic stress, BioMatrix’ distinctive formulas are designed to help restore optimal function of the critical body systems.

  • Clinician’s Choice
  • Targeted at preventing and resolving the impact of chronic stress, BioMatrix’ distinctive formulas are designed to help restore optimal function of the critical body systems.
  • Efficacy validated by pre- and post- laboratory test data.
  • Therapeutic levels of nutrients derived from the highest quality sources available.
  • Eliminates the need for multiple supplements resulting in improved patient compliance.
  • Highly bioavailable even in compromised digestive systems.
  • Decades of clinical experience represented in each formula.
  • Trusted by thousands of health professionals and their patients since 1998.
  • Manufactured in FDA cGMP compliant facilities.

The BioMatrix Support line offers a select group of supplements formulated to support protocols guided by lab results. The functional intent of each product is inherent in its name. Accept no imitations. BioMatrix formulas are used by thousands of health professionals and their patients to manage and reverse the physiological dysfunctions created by chronic stress and related illness.


Synergistics Europe:

Welcome to Synergistics Europe Ltd, the only Official, Sanctioned Source for Metabolic Typing® Supplements. Metabolic Type® and Metabolic Typing® are the Registered Trademarks of Healthexcel, Inc. and William L. Wolcott, who is recognised as the world’s leading authority on Metabolic Typing® and who has been researching, developing, and refining the science of Metabolic Typing® for over 40 years.

Synergistics Europe Ltd is an international company developed specifically to offer outstanding customer service to Health Care Professionals (Dr’s, Qualified Health Professionals (CMTA/FDN) and their patients/clients. We provide the highest quality products available anywhere in the world. These products have been specifically designed to support various metabolisms as determined by the Healthexcel System of Metabolic Typing®.

Synergistics Europe’s formulas are unique, having been manufactured in the USA exclusively by Ultra Life, Inc (since 1976). for the various Metabolic Types®.

All raw materials must meet exact standards of purity and potency. The finest state-of-the-art methods are employed in all aspects of production to maintains and preserve the highest nutritional value.

We are here to help, if you are unsure of any of the product details or how to take/administer the product, please do get in touch and we will endeavor to answer your questions and put your mind at ease!

Additional Info:

Learn more about Synergistics Europe

Learn more about Biomatrix

Bottle design may differ from those shown


  • Progesterone Per Drop: 4 mg.
  • Rice Bran Oil
  • USP Progesterone
  • Vitamin E (with mixed
  • Progesterone Per Drop: 4mg
  • Allergen-free. No corn, rice, soy, etc. No GMOs.