Magnesium Breakthrough – 60 Capsules – BIOptimizers

Usage Information

Take 1-2 Caps in the morning with or without food.

Take 1-2 Caps at night before bed with or without food.

Wades Tip :- If you are suffering from stress and/or burnout. It is recommended that you load magnesium see Wade’s program below.

WADE’S LOADING PHASE CLICK HERE

When you take magnesium in the morning, it supports brain function and stress response throughout the day. In the evening, high doses of magnesium promote relaxation and may help with sleep. Therefore, it is best to divide your magnesium supplement doses throughout the day. If that is not possible, take whenever you can.

It is better to take mineral supplements, such as magnesium, on an empty stomach because you will absorb it more efficiently. However, some people experience upset stomach, so they take it with food.

Studies of inorganic magnesium salts (oxide, chloride, and sulfate) found that stomach acid is necessary for magnesium absorption, so they need to be taken on an empty stomach. However, organic magnesium salts (citrate, glycinate, chelate, etc) are more readily absorbed even when taken with food.

Our bodies don’t store magnesium well. It is generally excreted from your system within 24 hours of intake. Therefore, it is important to take magnesium every day.

Store in a cool/dry place away from direct light.

Do not use it if pregnant or breastfeeding. Keep out of reach of children. As with any product, discontinue immediately if adverse effects occur. Please consult a physician before beginning a new supplement, diet, training program, or if you are undergoing treatment of a medical condition.

Info & Research

GET ALL 7 FORMS OF MAGNESIUM AND TRANSFORM YOUR STRESS AND PERFORMANCE

• Magnesium supplements to help with sleep
• Help to reduce your stress levels and feel relaxed and at peace
• Can support you getting to sleep faster and deeper
• Works to boost your immune system
• Helps with heart rhythm
• Contributes to building strong bones

Magnesium Breakthrough Benefits

Promotes Heart Health. Magnesium is extremely important for heart health[2] and blood vessel health. Magnesium deficiency seems to worsen the inflammation, blood vessel constriction, blood clotting, and stress responses that trigger heart conditions. Correcting deficiency appears to improve heart health and reduces risk of deaths, although it is unclear whether supplementation alone is sufficient to treat these conditions.

Improves the Ability to Deal With Stress and Helps to Relax. A magnesium supplement significantly reduced stress[3] in people who are deficient in magnesium. Also, combined[4] with vitamin B6 was 40% more helpful than alone for severe stress. Findings support the need for magnesium supplementation for people living in conditions of chronic stress.[5]

Helps With Mood, Cognitive Function, and Mental Health. A magnesium supplement significantly improved[6] mood[7] after 2 weeks. Another trial found that magnesium supplements improved[8] mood in seniors with type 2 diabetes.

Promotes Healthy Blood Sugar Hormone Function And Promotes Healthy Metabolism. Magnesium is important for hormones that regulate blood sugar[9] to function well. Therefore, many people with blood sugar issues,[10] metabolic syndrome, and diabetes are deficient in magnesium. Even when diabetes[11] is well-controlled, a supplement would still be necessary to achieve healthy levels. In a clinical trial involving 65 diabetes patients, magnesium supplementation promotes healthy function[12] and metabolism.

A large-scale systematic and dose-response analysis found that magnesium supplementation correlated with reduced body weight[13] and waist circumference among specific groups of people. Those with resistance, hypertension, obesity, magnesium deficiency, and women seem to weigh less and have smaller waist circumference if they took magnesium supplements.

In pregnant women with gestational diabetes[14], magnesium supplementation improved blood glucose control and pregnancy outcomes.

Supports exercise performance and recovery. Magnesium supplementation improves speed and strength,[15] possibly by making glucose metabolism more efficient. It also supports the necessary stress response to exercise, reduces muscle damage,[16] and improves exercise recovery (400 mg/day, taken at breakfast).

Improves Sleep Quality. In a small clinical trial involving 46 elderly subjects with insomnia,[17] 500 mg of daily magnesium supplement reduced insomnia scores, sleep latency, and cortisol. Subjects also had more serum melatonin, slept deeper, and were less likely to wake up in the middle of the night.

Builds Stronger Bones. Magnesium is a key building blocks of your bones.[18] Magnesium deficiency can contribute to osteoporosis by:

• preventing healthy bone formation, creating brittle bones
• causing low-grade inflammation
• increasing cortisol, which can contribute to bone loss
• reducing parathyroid hormone
• In a clinical trial[19] involving 73,684 postmenopausal women, low magnesium intake was associated with lower bone density in the hip and whole body. Magnesium intake slightly higher than the Recommended Dietary Allowance was associated with lower arm and wrist fractures from falling.

Promotes Healthy Blood Pressure. A meta-analysis of 34 randomized control trials found that magnesium reduced blood pressure.[20] However, the effect size is clinically small (<2 mmHg). Therefore, it may be good for supporting overall health and healthy blood pressure, but you may also need other interventions to achieve healthy blood pressure levels.

Promotes Balanced and Healthy Immune System. Magnesium deficiency[21] increases inflammation.[22] In a meta-analysis[23] involving 32,198 people, those with more magnesium had less serum C-reactive protein (a marker of inflammation).

Overall, magnesium deficiencies tend to exacerbate or increase the risk of conditions that involve chronic inflammation.[24]

Supports Vitamin D Activation and Metabolism. Both Vitamin D and magnesium have important roles in bone health, immune function, and metabolism. Magnesium is a cofactor in vitamin D conversion and activation.[25] Some people cannot increase their blood 25-hydroxy vitamin D levels despite supplementing with vitamin D3 because they are deficient. In other words, magnesium deficiency can make vitamin D ineffective.

Also, in people deficient, high doses of vitamin D3 could worsen magnesium deficiency and increase the potential for side effects of vitamin D3, such as having calcium deposits in the arteries.

[2] DiNicolantonio JJ, Liu J, O’Keefe JH. Magnesium for the prevention and treatment of cardiovascular disease. Open Heart. 2018;5(2):e000775. Published 2018 Jul 1. doi:10.1136/openhrt-2018-000775

[3] Boyle NB, Lawton C, Dye L. The Effects of magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429

[4] Pouteau E, Kabir-Ahmadi M, Noah L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454. Published 2018 Dec 18. doi:10.1371/journal.pone.0208454

[5] Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362-370. doi:10.1016/j.mehy.2006.01.047

[6] Tarleton EK, Littenberg B, MacLean CD, Kennedy AG, Daley C. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial. PLoS One. 2017;12(6):e0180067. Published 2017 Jun 27. doi:10.1371/journal.pone.0180067

[7] Botturi A, Ciappolino V, Delvecchio G, Boscutti A, Viscardi B, Brambilla P. The Role and the Effect of Magnesium in Mental Disorders: A Systematic Review. Nutrients. 2020;12(6):1661. Published 2020 Jun 3. doi:10.3390/nu12061661

[8] Barragán-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F. Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial. Magnes Res. 2008;21(4):218-223

[9] Guerrero-Romero F, Tamez-Perez HE, González-González G, et al. Oral magnesium supplementation improves sensitivity in non-diabetic subjects with resistance. A double-blind placebo-controlled randomized trial. Diabetes Metab. 2004;30(3):253-258. doi:10.1016/s1262-3636(07)70116-7

[10] Takaya J, Higashino H, Kobayashi Y. Intracellular magnesium and resistance. Magnes Res. 2004;17(2):126-136

[11] Schnack C, Bauer I, Pregant P, Hopmeier P, Schernthaner G. Hypomagnesaemia in type 2 diabetes mellitus is not corrected by improvement of long-term metabolic control. Diabetologia. 1992;35(1):77-79. doi:10.1007/BF00400855

[12] Rodríguez-Morán M, Guerrero-Romero F. Oral magnesium supplementation improves sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care. 2003;26(4):1147-1152. doi:10.2337/diacare.26.4.1147

[13] Askari M, Mozaffari H, Jafari A, Ghanbari M, Darooghegi Mofrad M. The effects of magnesium supplementation on obesity measures in adults: a systematic review and dose-response meta-analysis of randomized controlled trials [published online ahead of print, 2020 Jul 11]. Crit Rev Food Sci Nutr. 2020;1-17. doi:10.1080/10408398.2020.1790498

[14] Asemi Z, Karamali M, Jamilian M, et al. Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(1):222-229. doi:10.3945/ajcn.114.098616

[15] Córdova A, Mielgo-Ayuso J, Roche E, Caballero-García A, Fernandez-Lázaro D. Impact of Magnesium Supplementation in Muscle Damage of Professional Cyclists Competing in a Stage Race. Nutrients. 2019;11(8):1927. Published 2019 Aug 16. doi:10.3390/nu11081927

[16] Córdova A, Mielgo-Ayuso J, Roche E, Caballero-García A, Fernandez-Lázaro D. Impact of Magnesium Supplementation in Muscle Damage of Professional Cyclists Competing in a Stage Race. Nutrients. 2019;11(8):1927. Published 2019 Aug 16. doi:10.3390/nu11081927

[17] Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17(12):1161-1169

[18] Castiglioni S, Cazzaniga A, Albisetti W, Maier JA. Magnesium and osteoporosis: current state of knowledge and future research directions. Nutrients. 2013;5(8):3022-3033. Published 2013 Jul 31. doi:10.3390/nu5083022

[19] Orchard TS, Larson JC, Alghothani N, et al. Magnesium intake, bone mineral density, and fractures: results from the Women’s Health Initiative Observational Study. Am J Clin Nutr. 2014;99(4):926-933. doi:10.3945/ajcn.113.067488

[20] Zhang X, Li Y, Del Gobbo LC, et al. Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Hypertension. 2016;68(2):324-333. doi:10.1161/HYPERTENSIONAHA.116.07664

[21] Tam M, Gómez S, González-Gross M, Marcos A. Possible roles of magnesium on the immune system. Eur J Clin Nutr. 2003;57(10):1193-1197. doi:10.1038/sj.ejcn.1601689

[22] Moslehi N, Vafa M, Rahimi-Foroushani A, Golestan B. Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women. J Res Med Sci. 2012;17(7):607-614

[23] Kim DJ, Xun P, Liu K, et al. Magnesium intake in relation to systemic inflammation, resistance, and the incidence of diabetes. Diabetes Care. 2010;33(12):2604-2610. doi:10.2337/dc10-0994

[24] Nielsen FH. Magnesium deficiency and increased inflammation: current perspectives. J Inflamm Res. 2018;11:25-34. Published 2018 Jan 18. doi:10.2147/JIR.S136742

[25] Uwitonze AM, Razzaque MS. Role of Magnesium in Vitamin D Activation and Function. J Am Osteopath Assoc. 2018;118(3):181-189. doi:10.7556/jaoa.2018.03

Supplement Facts

Serving Size: 2 capsules

60 caps per bottle

Product Dimensions:

Cap diameter: 1.5 inches

Bottom diameter: 2 inches

Height: 4 inches

Weight: 3.05 ounces

Made in the USA.

Suitable for vegetarians and vegans.

Store in a cool/dry place away from direct light.